Incidence, Duration, and Reappearance of Type-Specific Cervical Human Papillomavirus Infections in Young Women
Ralph P Insinga, Gonzalo Perez, Cosette M Wheeler, Laura A Koutsky, Suzanne M Garland, Sepp Leodolter, Elmar A Joura, Daron G Ferris, Marc Steben, Darron R Brown, Elamin H Elbasha, Jorma Paavonen, Richard M Haupt
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION | AMER ASSOC CANCER RESEARCH | Published : 2010
BACKGROUND: We describe the incidence and duration of cervical human papillomavirus (HPV) infection episodes along with the risk of infection reappearance following a period of nondetection. METHODS: Women (1,788) ages 16 to 23 years underwent cytologic testing and PCR-based testing of cervical swab samples for HPV DNA (HPV-16/18/31/33/35/45/52/58/59) at approximately 6-month intervals for up to 4 years in the context of a phase 3 clinical trial (placebo arm). HPV type-specific incidence rates were estimated per 100 person-years. Duration of type-specific cervical infection episodes and risk of reappearance following a period of nondetection were estimated using Kaplan-Meier methods. RESULTS..View full abstract
Merck Research Laboratories.