Journal article
Homeobox gene HLX is a regulator of HGF/c-met-mediated migration of human trophoblast-derived cell lines
G Rajaraman, P Murthi, SP Brennecke, B Kalionis
Biology of Reproduction | OXFORD UNIV PRESS INC | Published : 2010
Abstract
Homeobox gene transcription factors play a critical role in normal placental development and are expressed in specialized trophoblast cells. Abnormal trophoblast function is associated with clinically significant pregnancy disorders, including fetal growth restriction (FGR). Our previous studies demonstrated that homeobox gene HLX is expressed in proliferating and migrating (but not invading) human trophoblast cells and that HLX expression is significantly decreased in human FGR. We have also shown that HLX is a regulator of colony-stimulating-factor-1-dependent trophoblast proliferation. Hepatocyte growth factor (HGF) activates trophoblast cell migration in a paracrine fashion, and its rece..
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Awarded by NHMRC
Funding Acknowledgements
Supported by NHMRC project grant 509140, the Lynne Quayle Charitable Trust Fund (Equity Trustees), the Marian EH Hack Trust, and a University of Melbourne Early Career Researcher Grant (to P.M.). G.R. was supported by a Felix Myer Postgraduate Scholarship from the University of Melbourne and a Royal Women's Hospital Postgraduate Scholarship.