Journal article

Placental Biglycan Expression is Decreased in Human Idiopathic Fetal Growth Restriction

P Murthi, FA Faisal, G Rajaraman, J Stevenson, V Ignjatovic, PT Monagle, SP Brennecke, JM Said

PLACENTA | W B SAUNDERS CO LTD | Published : 2010


Fetal growth restriction (FGR) is a leading cause of perinatal morbidity and mortality. The majority of FGR cases are idiopathic and are associated with placental insufficiency, which can result from placental thrombosis. Evidence suggests that Dermatan Sulfate (DS) is an important anti-coagulant in placentae of uncomplicated pregnancies. This study hypothesised that the expression of biglycan proteoglycan, a source of DS, is decreased in idiopathic FGR placentae compared with placentae from uncomplicated pregnancies. This study aimed to determine biglycan mRNA, protein expression and spatial distribution in idiopathic FGR placentae compared with the placentae from gestation-matched controls..

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Funding Acknowledgements

The authors would like to thank Clinical Research Midwives, Ms Susan Nisbet and Ms Sue Duggan for specimen collection and other staff in the Department of Perinatal Medicine, Pregnancy Research Centre at The Royal Women's Hospital. We would also like to thank the Royal Australian and New Zealand College of Obstetrics and Gynaecology Research Foundation for the Glyn White Scholarship and Campbell Edwards Trust for the Philanthropic Grant, which provided funding support for this project.