Journal article

Aprataxin Tumor Levels Predict Response of Colorectal Cancer Patients to Irinotecan-based Treatment

Higinio Dopeso, Silvia Mateo-Lozano, Elena Elez, Stefania Landolfi, Francisco Javier Ramos Pascual, Javier Hernandez-Losa, Rocco Mazzolini, Paulo Rodrigues, Sarah Bazzocco, Maria Josep Carreras, Eloy Espin, Manel Armengol, Andrew J Wilson, John M Mariadason, Santiago Ramon y Cajal, Josep Tabernero, Simo Schwartz, Diego Arango

CLINICAL CANCER RESEARCH | AMER ASSOC CANCER RESEARCH | Published : 2010

Abstract

PURPOSE: Irinotecan (CPT11) treatment significantly improves the survival of colorectal cancer patients and is routinely used for the treatment of these patients, alone or in combination with other agents. However, only 20% to 30% of patients show an objective response to irinotecan, and there is great need for new molecular markers capable of identifying the subset of patients who are unlikely to respond. EXPERIMENTAL DESIGN: Here we used microarray analysis of a panel of 30 colorectal cancer cell lines and immunohistochemistry to identify and validate a new biomarker of response to irinotecan. RESULTS: A good correlation was observed between irinotecan sensitivity and the expression of apr..

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University of Melbourne Researchers