Journal article
Gastric leptin: A novel role in cardiovascular regulation
DM Sartor, AJM Verberne
American Journal of Physiology Heart and Circulatory Physiology | AMER PHYSIOLOGICAL SOC | Published : 2010
Abstract
Gastric-derived leptin affects satiety and gastrointestinal function via vagal mechanisms and has been shown to interact with the gut hormone cholecystokinin (CCK). CCK selectively inhibits splanchnic sympathetic nerve discharge (SND) and the activity of a subset of presympathetic vasomotor neurons in the rostroventrolateral medulla (RVLM). The present study sought to examine the effects of gastric leptin on arterial pressure (AP), heart rate (HR), SND, and RVLM neuronal activity to determine whether its effects on cardiovascular regulation are dependent on CCK1 receptors and vagal afferent transmission. To mimic gastric leptin, leptin (15-30 μg/kg) was administered close to the coeliac arte..
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Funding Acknowledgements
This study was supported by an Australia and New Zealand Medical Research and Technology in Victoria Grant, a University of Melbourne Early Career Research Grant ( to D. M. Sartor), and The National Health and Medical Research Council of Australia.