A comparison of pregabalin, lamotrigine, and placebo as adjunctive therapy in patients with refractory partial-onset seizures
Michel Baulac, Teresa Leon, Terence J O'Brien, Edward Whalen, Jeannette Barrett
EPILEPSY RESEARCH | ELSEVIER SCIENCE BV | Published : 2010
PURPOSE: This study assessed the comparative efficacy of pregabalin for refractory partial seizures. METHODS: Four-hundred and thirty-four patients with partial seizures were randomized to pregabalin, lamotrigine, or placebo as adjunctive therapy for 17 weeks of double-blind treatment. In phase I (11 weeks), pregabalin was titrated over 1 week and lamotrigine over 5 weeks to fixed dosages of 300mg/day for both. In phase II (6 weeks), patients not yet seizure-free were increased to pregabalin 600mg/day or lamotrigine 400mg/day. RESULTS: During phase I, there was a nonsignificant trend toward a greater reduction in seizures with pregabalin versus placebo and lamotrigine. Across the 17 weeks of..View full abstract
This study was funded by Pfizer Inc. Editorial support was provided by Thomas Hedberg and Elizabeth Young of UBC Scientific Solutions and funded by Pfizer Inc.