Journal article

Cadherins in the human placenta - epithelial-mesenchymal transition (EMT) and placental development

MI Kokkinos, P Murthi, R Wafai, EW Thompson, DP Newgreen

PLACENTA | W B SAUNDERS CO LTD | Published : 2010


Colonisation of the maternal uterine wall by the trophoblast involves a series of alterations in the behaviour and morphology of trophoblast cells. Villous cytotrophoblast cells change from a well-organised coherently layered phenotype to one that is extravillous, acquiring a proliferative, migratory and invasive capacity, to facilitate fetal-maternal interaction. These changes are similar to those of other developmental processes falling under the umbrella of an epithelial-mesenchymal transition (EMT). Modulation of cell adhesion and cell polarity occurs through changes in cell-cell junctional molecules, such as the cadherins. The cadherins, particularly the classical cadherins (e.g. Epithe..

View full abstract