Journal article
Seizure severity and duration in the cortical stimulation model of experimental epilepsy in rats: A longitudinal study
TS Nelson, CL Suhr, A Lai, AJ Halliday, DR Freestone, KJ McLean, AN Burkitt, MJ Cook
Epilepsy Research | ELSEVIER | Published : 2010
Abstract
The aim of this study was to determine the current intensities necessary to elicit three levels of varying EEG and behavioural phenomena with electrical stimulation, and also to determine the consistency of the EEG and behavioural components of the triggered seizures over time. Electrical stimulation of the primary motor/somatosensory cortex was performed in 16 adult rats with multichannel microwire electrode arrays. Stimulation was delivered at a frequency of 60. Hz (1. ms pulse width), for 2. s duration, as biphasic rectangular pulses over four of the eight available electrode pairs. Current intensity thresholds for interruption of normal behaviour, epileptiform afterdischarge (EAD) longer..
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Funding Acknowledgements
The authors wish to acknowledge the support of the State Government of Victoria through the Science and Technology Innovation Initiative and the assistance of Associate Professor Antonio Paolini in the initial establishment of the laboratory facilities. The Bionic Ear Institute acknowledges the support it receives from the Victorian Government through its Operational Infrastructure Support Program and the Helen Macpherson Smith Trust.