Journal article

Clinical utility of distributed source modelling of interictal scalp EEG in focal epilepsy

C Plummer, M Wagner, M Fuchs, S Vogrin, L Litewka, S Farish, C Bailey, AS Harvey, MJ Cook



OBJECTIVE: Assess the clinical utility of non-invasive distributed EEG source modelling in focal epilepsy. METHODS: Interictal epileptiform discharges were recorded from eight patients - benign focal epilepsy of childhood (BFEC), four; mesial temporal lobe epilepsy (MTLE), four. EEG source localization (ESL) applied 48 forward-inverse-subspace set-ups: forward - standardized, leadfield-interpolated boundary element methods (BEMs, BEMi), finite element method (FEMi); inverse - minimum norm (MNLS), L1 norm (L1), low resolution electromagnetic tomography (LORETA), standardized LORETA (sLORETA); subspace- whole volume (3D), cortex with rotating sources (CxR), cortex with fixed sources (CxN), cor..

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Funding Acknowledgements

Compumedics Neuroscan (R) supplied the Scan 4.3 (R) and CURRY 5.0 (R) software programs. The first author held an Australian National Health and Medical Research Council Postgraduate Medical Research Scholarship. Drs. Michael Wagner and Manfred Fuchs are employees of Compumedics Neuroscan (R). Their contributions to the study were restricted to the provision of technical and mathematical advice. Technical assistance also provided by Ms. Linda Seiderer and Ms. Natasha Willems.