Dipole versus distributed EEG source localization for single versus averaged spikes in focal epilepsy

Abstract

The aim of this study is to characterize and compare dipole and distributed EEG source localization (ESL) of interictal epileptiform discharges (IEDs) in focal epilepsy. Single and averaged scalp IEDs from eight patients-four with benign focal epilepsy of childhood with centrotemporal spikes (BFEC) and four with mesial temporal lobe epilepsy (MTLE)-underwent independent component analysis (ICA) from IED onset to peak. The boundary element method forward model was applied to one of four inverse models: two dipolar-moving regularized, rotating nonregularized and two distributed-standardized low-resolution electromagnetic tomography with rotating cortical sources or with fixed extended sources...