Journal article
Two novel point mutations in clinical Staphylococcus aureus reduce linezolid susceptibility and switch on the stringent response to promote persistent infection
W Gao, K Chua, JK Davies, HJ Newton, T Seemann, PF Harrison, NE Holmes, HW Rhee, JI Hong, EL Hartland, TP Stinear, BP Howden
Plos Pathogens | PUBLIC LIBRARY SCIENCE | Published : 2010
Open access
Abstract
Staphylococcus aureus frequently invades the human bloodstream, leading to life threatening bacteremia and often secondary foci of infection. Failure of antibiotic therapy to eradicate infection is frequently described; in some cases associated with altered S. aureus antimicrobial resistance or the small colony variant (SCV) phenotype. Newer antimicrobials, such as linezolid, remain the last available therapy for some patients with multi-resistant S. aureus infections. Using comparative and functional genomics we investigated the molecular determinants of resistance and SCV formation in sequential S. aureus isolates from a patient who had a persistent and recurrent S. aureus infection, after..
View full abstractGrants
Awarded by MEST
Funding Acknowledgements
This work was supported by the National Health and Medical Research Council, Australia, and The Austin Hospital Medical Research Foundation. A career development training fellowship from the National Health and Medical Research Council, Australia, supported Timothy P. Stinear. Jong-In Hong was supported by a NRF grant funded by the MEST (Grant No. 2009-0080734). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.