Journal article

Uteroplacental insufficiency programs regional vascular dysfunction and alters arterial stiffness in female offspring

Marc Q Mazzuca, Mary E Wlodek, Nicoleta M Dragomir, Helena C Parkington, Marianne Tare



Intrauterine growth restriction caused by uteroplacental insufficiency increases the risk of cardiovascular disease in adulthood. Vascular mechanisms in female offspring are poorly understood. The aim of this study was to investigate the effects of uteroplacental insufficiency on blood pressure, vascular reactivity and arterial stiffness in four vascular beds in female offspring born growth restricted. Uteroplacental insufficiency was induced on day 18 of gestation in Wistar Kyoto rats by bilateral uterine vessel ligation (Restricted) or sham surgery (Controls). Wire and pressure myography were used to test endothelial and smooth muscle function, and passive mechanical wall properties, respe..

View full abstract


Funding Acknowledgements

Authors were supported by the National Health and Medical Research Council of Australia. M.Q.M. was supported by a Kidney Health Australia Biomedical Scholarship and The University of Melbourne Fee Remission Scholarship. We thank Dr Andrew Siebel, Dr Laura Parry, Kerryn Westcott, Tania Romano, Amy Mibus, Dr Lenka Vodstrcil, Ian Boundy, Bruce Abaloz and Sandy Clarke (Statistical Consulting Centre, University of Melbourne) for their valuable contributions.