Journal article

Expression of Angiotensin Type 1A Receptors in C1 Neurons Restores the Sympathoexcitation to Angiotensin in the Rostral Ventrolateral Medulla of Angiotensin Type 1A Knockout Mice

Daian Chen, Jaspreet K Bassi, Thomas Walther, Walter G Thomas, Andrew M Allen

HYPERTENSION | LIPPINCOTT WILLIAMS & WILKINS | Published : 2010

Abstract

In adult mice we determined whether expression of angiotensin II (Ang II) type 1A receptors (AT(1A)Rs) in C1 neurons mediates the excitation of the rostral ventrolateral medulla (RVLM) by Ang II. Blood pressure, heart rate, and sympathetic nerve activity were measured in anesthetized, artificially ventilated wild-type (n=15) and AT(1A)R knockout (AT(1A)(-/-); n=9) mice. Microinjection of Ang II (50 nL of 0.1 to 1.0 mmol/L) into the RVLM induced a dose-related, sympathetically mediated pressor response (maximum of 17+/-2 mm Hg) in wild-type mice. These microinjections had no effect in AT(1A)(-/-) mice. Endogenous AT(1)Rs occur on catecholaminergic C1 neurons in the RVLM. We induced AT(1A)R or..

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Grants

Awarded by Australian National Health and Medical Research Council


Awarded by National Heart Foundation of Australia


Awarded by Australian Research Council


Funding Acknowledgements

This work was supported by funding from the Australian National Health and Medical Research Council (No. 566563), the National Heart Foundation of Australia (G07M3186), the Australian Research Council (DP1094301), and the Rebecca L. Cooper Medical Research Foundation.