Journal article
Cognitive performance and leukocyte telomere length in two narrow age-range cohorts: A population study
KA Mather, AF Jorm, KJ Anstey, PJ Milburn, S Easteal, H Christensen
BMC Geriatrics | BIOMED CENTRAL LTD | Published : 2010
Open access
Abstract
Background: Cognitive function and telomere length both decline with age. A correlation between these two measures would suggest that they may be influenced by the same underlying age-related biological process. Several studies suggest telomere length may be positively correlated with cognitive performance but the evidence is equivocal. In this report, the relationships between telomere length and cognitive performance at Wave 2 and cognitive change from Wave 1 to Wave 2 are assessed in two narrow age-range population cohorts. Methods: We tested the hypothesis that leukocyte telomere length correlates positively with cognitive performance and cognitive decline in two community cohorts of mid..
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Awarded by Australian Association of Gerontology
Funding Acknowledgements
We would like to acknowledge and express our gratitude to the PATH respondents, for without their contributions this study would not have been possible. The authors would also like to thank the PATH Project staff. We are also grateful to Dr. Ruth Parslow from the Australian Centre for Post-Traumatic Mental Health, University of Melbourne for insightful discussions regarding this work. We would also like to acknowledge the support and expertise of Ms. Xiaoyun Tan from the John Curtin School of Medical Research, Australian National University. This work was supported by an Australian National Health and Medical Research Council Program Grant 179805 and an R. M. Gibson Grant from the Australian Association of Gerontology. A. F. Jorm, K.J. Anstey and H. Christensen are funded by NHMRC Fellowships.