Iron-Export Ferroxidase Activity of beta-Amyloid Precursor Protein Is Inhibited by Zinc in Alzheimer's Disease
James A Duce, Andrew Tsatsanis, Michael A Cater, Simon A James, Elysia Robb, Krutika Wikhe, Su Ling Leong, Keyla Perez, Timothy Johanssen, Mark A Greenough, Hyun-Hee Cho, Denise Galatis, Robert D Moir, Colin L Masters, Catriona McLean, Rudolph E Tanzi, Roberto Cappai, Kevin J Barnham, Giuseppe D Ciccotosto, Jack T Rogers Show all
Cell | CELL PRESS | Published : 2010
Awarded by National Institute on Aging
This work was supported by funds from the National Institute on Aging (1RO1AG12686), the Australian Research Council, the Australian National Health & Medical Research Council (NHMRC), Operational Infrastructure Support Victorian State Government, and the Alzheimer's Association. The Victorian Brain Bank Network is supported by The University of Melbourne, The Mental Health Research Institute, The Alfred Hospital, and the Victorian Forensic Institute of Medicine and funded by Neurosciences Australia and the NHMRC. We thank Gerd Multhaup for helpful comments and for providing APP reagents for pilot studies, Paul Adlard for human tissue samples, and Wilma Wasco for the APLP2 construct. C. L. M., R. E. T., K.J.B., and A. I. B. are shareholders, paid consultants, and advisory board members of Prana Biotechnology Ltd. A.I.B. is a shareholder of Cogstate Ltd and Eucalyptus Biosciences Pty Ltd. M. A. C. is a shareholder in Prana Biotechnology Ltd.