Severe developmental bone phenotype in ClC-7 deficient mice
AV Neutzsky-Wulff, NA Sims, C Supanchart, U Kornak, D Felsenberg, IJ Poulton, TJ Martin, MA Karsdal, K Henriksen
DEVELOPMENTAL BIOLOGY | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2010
Bone development is dependent on the functionality of three essential cell types: chondrocytes, osteoclasts and osteoblasts. If any of these cell types is dysfunctional, a developmental bone phenotype can result. The bone disease osteopetrosis is caused by osteoclast dysfunction or impaired osteoclastogenesis, leading to increased bone mass. In ClC-7 deficient mice, which display severe osteopetrosis, the osteoclast malfunction is due to abrogated acidification of the resorption lacuna. This study sought to investigate the consequences of osteoclast malfunction on bone development, bone structure and bone modeling/remodeling in ClC-7 deficient mice. Bones from wildtype, heterozygous and ClC-..View full abstract
Awarded by NHMRC (Australia)
Awarded by German Federal Ministry of Education and Research (BMBF)
We gratefully acknowledge the funding from the Danish Research Foundation (Den Danske Forskningsfond) supporting this work, as well as the funds received from the Danish Ministry of "Science, Technology and Innovation". This project has received funds from the Danish Ministry of "Science, Technology and Innovation" as they have funded the PhD education of Anita V. Neutzsky-Wulff. Funds for this project have also been given from the Danish Research Foundation (Den Danske Forskningsfond). The work was supported by NHMRC (Australia) Program Grant 345401 to Natalie A. Sims and T. J. Martin, and Natalie A. Sims is supported by a NHMRC (Australia) Senior Research Fellowship. This study was supported by the German Federal Ministry of Education and Research (BMBF) by grant 01GM0623 (SKELNET) to Uwe Kornak.