The TAL1/SCL Transcription Factor Regulates Cell Cycle Progression and Proliferation in Differentiating Murine Bone Marrow Monocyte Precursors
Soumyadeep Dey, David J Curtis, Stephen M Jane, Stephen J Brandt
MOLECULAR AND CELLULAR BIOLOGY | AMER SOC MICROBIOLOGY | Published : 2010
Monocytopoiesis involves the stepwise differentiation in the bone marrow (BM) of common myeloid precursors (CMPs) to monocytes. The basic helix-loop-helix transcription factor TAL1/SCL plays a critical role in other hematopoietic lineages, and while it had been reported to be expressed by BM-derived macrophages, its role in monocytopoiesis had not been elucidated. Using cell explant models of monocyte/macrophage (MM) differentiation, one originating with CMPs and the other from more committed precursors, we characterized the phenotypic and molecular consequences of inactivation of Tal1 expression ex vivo. While Tal1 knockout had minimal effects on cell survival and slightly accelerated termi..View full abstract
Awarded by National Institutes of Health
Awarded by NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
This work was supported by grant R01 HL049118 from the National Institutes of Health and a Merit Review Award from the Department of Veterans Affairs (both to S. J. B.).