The Molecular Basis of Lmo2-Induced T-Cell Acute Lymphoblastic Leukemia
David J Curtis, Matthew P McCormack
CLINICAL CANCER RESEARCH | AMER ASSOC CANCER RESEARCH | Published : 2010
T-cell acute lymphoblastic leukemia (T-ALL) is commonly caused by the overexpression of oncogenic transcription factors in developing T cells. In a mouse model of one such oncogene, LMO2, the cellular effect is to induce self-renewal of committed T cells in the thymus, which persist long-term while acquiring additional mutations and eventually giving rise to leukemia. These precancerous stem cells (pre-CSC) are intrinsically resistant to radiotherapy, implying that they may be refractory to conventional cancer therapies. However, they depend on an aberrantly expressed stem cell-like self-renewal program for their maintenance, in addition to a specialized thymic microenvironmental niche. Here..View full abstract
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Awarded by National Health and Medical Research Council of Australia (NHMRC)
D.J. Curtis and M.P. McCormack were supported by a grant from the National Health and Medical Research Council of Australia (NHMRC; project grant 628386). D.J. Curtis is an RD Wright Biomedical Research Fellow of the NHMRC.