Journal article

Preliminary evidence of ethnic divergence in associations of putative genetic variants for methamphetamine dependence

Chad A Bousman, Stephen J Glatt, Mariana Cherner, J Hampton Atkinson, Igor Grant, Ming T Tsuang, Ian P Everall

PSYCHIATRY RESEARCH | ELSEVIER IRELAND LTD | Published : 2010

Abstract

Research into the biological processes that increase susceptibility to methamphetamine dependence has been conducted primarily in Asian populations. Using a case-control design this study's purpose was to explore, among a population of methamphetamine-dependent Caucasians, six putative single nucleotide polymorphisms previously found to be associated with methamphetamine dependence in Asian populations. A total of 193 non-psychotic males (117 methamphetamine-dependent and 76 controls) were genotyped for variants located in six genes (AKT1, ARRB2, BDNF, COMT, GSTP1, OPRM1). Genotypic and allelic frequencies, odds ratios, and 95% confidence intervals were calculated. None of the putative gene ..

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Grants

Awarded by United States National Institutes of Health


Awarded by NATIONAL INSTITUTE OF MENTAL HEALTH


Awarded by NATIONAL INSTITUTE ON DRUG ABUSE


Funding Acknowledgements

The authors wish to acknowledge support from the United States National Institutes of Health (grant numbers P01-DA12065 and P30-MH62512) and the contributions of study participants and staff at the HIV Neurobehavioral Research Center (HNRC), San Diego, CA, USA. The views expressed in this article are those of the authors and do not reflect the official policy or position of the Department of the Navy. Department of Defense, nor the United States Government.