Journal article

Positive Symptoms of Psychosis Correlate With Expression of Ubiquitin Proteasome Genes in Peripheral Blood

Chad A Bousman, Gursharan Chana, Stephen J Glatt, Sharon D Chandler, Todd May, James Lohr, William S Kremen, Ming T Tsuang, Ian P Everall

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS | WILEY | Published : 2010

Abstract

Several brain- and blood-based gene expression studies in patients with psychotic disorders (e.g., schizophrenia) have identified genes in the ubiquitin proteasome system (UPS) pathway as putative biomarkers. However, to date an examination of the UPS pathway in the broader context of symptom severity in psychosis has not been conducted. The purpose of this study was to investigate the correlation between clinical scores on the Scales for the Assessment of Positive and Negative Symptoms (SAPS-SANS) and expression of 43 highly annotated genes within the UPS pathway in blood from patients with psychosis. A sample of 19 psychotic patients diagnosed with schizophrenia (n = 13) or bipolar disorde..

View full abstract

Grants

Awarded by National Institutes of Health



Awarded by NATIONAL INSTITUTE OF MENTAL HEALTH


Awarded by NATIONAL INSTITUTE ON AGING


Awarded by NATIONAL INSTITUTE ON DRUG ABUSE


Funding Acknowledgements

This work was supported by R21MH075027 (M.T.T.) as well as in part by the UCSD Center for AIDS Research Genomics Core, and National Institutes of Health grants R01MH079881, R25MH074508, R25MH081482, and R41MH079728 (I.P.E.), R01AG018386, R01AG022381, and R01AG022982 (W.S.K.), R01DA012846, R01DA018662, R01MH065562, and R01MH071912 (M.T.T.), R01MH085521, P50MH 081755-020003, and a NARSAD Young Investigator Award (S.J.G.).