Cytochrome P450-2D6 extensive metabolizers are more vulnerable to methamphetamine-associated neurocognitive impairment: Preliminary findings
Mariana Cherner, Chad Bousman, Ian Everall, Daniel Barron, Scott Letendre, Florin Vaida, J Hampton Atkinson, Robert Heaton, Igor Grant
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY | CAMBRIDGE UNIV PRESS | Published : 2010
While neuropsychological deficits are evident among methamphetamine (meth) addicts, they are often unrelated to meth exposure parameters such as lifetime consumption and length of abstinence. The notion that some meth users develop neuropsychological impairments while others with similar drug exposure do not, suggests that there may be individual differences in vulnerability to the neurotoxic effects of meth. One source of differential vulnerability could come from genotypic variability in metabolic clearance of meth, dependent on the activity of cytochrome P450-2D6 (CYP2D6). We compared neuropsychological performance in 52 individuals with a history of meth dependence according with their C..View full abstract
Awarded by United States National Institutes of Health
Awarded by NATIONAL INSTITUTE OF MENTAL HEALTH
Awarded by NATIONAL INSTITUTE ON DRUG ABUSE
This manuscript has never been published either electronically or in print. Portions of the information contained in the manuscript have been previously presented at the International Neuropsychological Society Mid-Year Meeting, July 2008, Buenos Aires, Argentina and the XVth World Congress on Psychiatric Genetics, Oct 2008, Osaka, Japan. The authors wish to acknowledge support from the United States National Institutes of Health (grant numbers R03-DA27513, P01-DA12065, and P30-MH62512) and the contributions of study participants and staff at the HIV Neurobehavioral Research Center (HNRC) and Translational Methamphetamine AIDS Research Center, San Diego, CA, USA.