Journal article
Hepatitis B surface antigen levels during the natural history of chronic hepatitis B: A perspective on Asia
T Nguyen, AJV Thompson, S Bowden, C Croagh, S Bell, PV Desmond, M Levy, SA Locarnini
Journal of Hepatology | Published : 2010
Abstract
Background & Aims: Data from clinical trials suggest a potential role for on-treatment monitoring of serum HBsAg titres during interferon-alpha (pegIFN) therapy in predicting virological responses. However, baseline HBsAg titres during the natural history of chronic hepatitis B (CHB) have not been well-characterized. We aimed to define the serum HBsAg titres during the different phases of CHB in a cohort of Asian patients infected with either genotype B or C HBV. Methods: Two-hundred and twenty patients were classified into immune-tolerant (IT), immune-clearance (IC), non/low-replicative (LR) or hepatitis B e antigen negative hepatitis (ENH) phases. Serum HBsAg was quantified using the ARCHI..
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Funding Acknowledgements
The authors who have taken part in this study declared that they do not have anything to declare regarding funding from industry or conflict of interest with respect to this manuscript. This work was supported by a Postgraduate Scholarship from the Gastroenterological Society of Australia (GESA). SL has been in receipt of a consultancy for Abbott Diagnostics Division. Abbott Diagnostics (Abbott Laboratories, Chicago, USA) provided the Architect Instrument for quantitative serological testing.