Journal article

Chemical Coding for Cardiovascular Sympathetic Preganglionic Neurons in Rats

David G Gonsalvez, Ilan A Kerman, Robin M McAllen, Colin R Anderson

JOURNAL OF NEUROSCIENCE | SOC NEUROSCIENCE | Published : 2010

Abstract

Cocaine and amphetamine-regulated transcript peptide (CART) is present in a subset of sympathetic preganglionic neurons in the rat. We examined the distribution of CART-immunoreactive terminals in rat stellate and superior cervical ganglia and adrenal gland and found that they surround neuropeptide Y-immunoreactive postganglionic neurons and noradrenergic chromaffin cells. The targets of CART-immunoreactive preganglionic neurons in the stellate and superior cervical ganglia were shown to be vasoconstrictor neurons supplying muscle and skin and cardiac-projecting postganglionic neurons: they did not target non-vasoconstrictor neurons innervating salivary glands, piloerector muscle, brown fat,..

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Grants

Awarded by National Institutes of Health (NIH)


Awarded by NATIONAL CENTER FOR RESEARCH RESOURCES


Awarded by NATIONAL INSTITUTE OF MENTAL HEALTH


Awarded by NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE


Funding Acknowledgements

I.A.K. was supported by National Institutes of Health (NIH) Grant 5K99MH081927-02 and a National Alliance for Research on Schizophrenia and Depression Young Investigator Award. Pseudorabies virus strains used in this work were provided by Lynn Enquist (Department of Molecular Biology and Princeton Neuroscience Institute, Princeton University, Princeton, NJ), who acknowledges funding from NIH Grants P40 RR 018604 and R37 NS 033506. We acknowledge the expert technical assistance of Jan Morgan and Dr. Peter Howe for the kind gift of PNMT antiserum.