Association between maternal serum cytokine profiles at 7-10 weeks' gestation and birthweight in small for gestational age infants
Harry M Georgiou, Yulinda S Thio, Chris Russell, Michael Permezel, Yujing J Heng, Stephen Lee, Stephen Tong
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY | MOSBY-ELSEVIER | Published : 2011
OBJECTIVE: The purpose of this study was to investigate whether birth of a small-for-gestational-age (SGA) baby (birthweight, <10th percentile) is preceded by altered maternal serum cytokine profiles at early pregnancy, compared with control babies (birthweight, 30-80th percentile). STUDY DESIGN: A retrospective case-control study of maternal serum collected prospectively across 7-10 weeks of gestation from women attending their first prenatal visit (SGA, 57 cases; control subjects, 71 cases selected retrospectively). Serum concentrations of 27 cytokines were measured in each sample and analyzed by 2-way analysis of variance and nonparametric tests. Logistic regression was used for predictiv..View full abstract
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Awarded by National Health and Medical Research Council of Australia
Supported by the Medical Research Foundation for Women and Babies and The National Health and Medical Research Council of Australia, Grant nos. 509127 (H.M.G., S.T.), 490970 (S.T.), and 454880 (Y.J.H.).