Journal article

Association between maternal serum cytokine profiles at 7-10 weeks' gestation and birthweight in small for gestational age infants

Harry M Georgiou, Yulinda S Thio, Chris Russell, Michael Permezel, Yujing J Heng, Stephen Lee, Stephen Tong

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY | MOSBY-ELSEVIER | Published : 2011

Abstract

OBJECTIVE: The purpose of this study was to investigate whether birth of a small-for-gestational-age (SGA) baby (birthweight, <10th percentile) is preceded by altered maternal serum cytokine profiles at early pregnancy, compared with control babies (birthweight, 30-80th percentile). STUDY DESIGN: A retrospective case-control study of maternal serum collected prospectively across 7-10 weeks of gestation from women attending their first prenatal visit (SGA, 57 cases; control subjects, 71 cases selected retrospectively). Serum concentrations of 27 cytokines were measured in each sample and analyzed by 2-way analysis of variance and nonparametric tests. Logistic regression was used for predictiv..

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