Journal article
Comprehensive, quantitative mapping of T cell epitopes in gluten in celiac disease
JA Tye-Din, JA Stewart, JA Dromey, T Beissbarth, DA Van Heel, A Tatham, K Henderson, SI Mannering, C Gianfrani, DP Jewell, AVS Hill, J McCluskey, J Rossjohn, RP Anderson
Science Translational Medicine | Published : 2010
Abstract
Celiac disease is a genetic condition that results in a debilitating immune reaction in the gut to antigens in grain. The antigenic peptides recognized by the T cells that cause this disease are incompletely defined. Our understanding of the epitopes of pathogenic CD4+ T cells is based primarily on responses shown by intestinal T cells in vitro to hydrolysates or polypeptides of gluten, the causative antigen. A protease-resistant 33-amino acid peptide from wheat a-gliadin is the immunodominant antigen, but little is known about the spectrum of T cell epitopes in rye and barley or the hierarchy of immunodominance and consistency of recognition of T cell epitopes in vivo. We induced polyclonal..
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Awarded by German National Genome Research Network by the Federal Ministry of Education and Research
Awarded by Wellcome Trust
Awarded by Juvenile Diabetes Research Foundation
Awarded by NHMRC
Awarded by NHMRC Independent Research Institutes
Funding Acknowledgements
J.A.T.-D. was supported by a National Health and Medical Research Council (NHMRC) Postgraduate Medical Scholarship and by a grant from the Australian and New Zealand Coeliac Research Fund; T.B. was supported by grant PBF-S19T10 of the German National Genome Research Network by the Federal Ministry of Education and Research; D.A.v.H. was funded by a Wellcome Trust Clinician Scientist Fellowship (GR068094MA); S.I.M. is supported by the Juvenile Diabetes Research Foundation (10-2006-261); J.R. is supported by an Australian Research Council Federation Fellowship; and R.P.A. holds the Ian Mackay Fellowship from the Walter and Eliza Hall Institute and Melbourne Health and also the Lions Cancer Council Fellowship. This work was supported by NHMRC Project grant 406656, Coeliac UK Project grant, the Graham Bird Memorial Fund (Oxford), the Oxford University College Challenge Seed Fund, BTG International plc, Nexpep Pty Ltd., the NHMRC Independent Research Institutes Infrastructure Support Scheme grant 361646, and Victorian State Government Operational Infrastructure Support.