Circulating Steroid Hormone Levels and Risk of Breast Cancer for Postmenopausal Women
Laura Baglietto, Gianluca Severi, Dallas R English, Kavitha Krishnan, John L Hopper, Catriona McLean, Howard A Morris, Wayne D Tilley, Graham G Giles
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION | AMER ASSOC CANCER RESEARCH | Published : 2010
Epidemiologic studies have consistently reported that endogenous steroid hormone levels are associated with postmenopausal breast cancer risk, but little is known on the associations by tumor grade, hormone receptor status, or age at diagnosis. We performed a case-cohort study of naturally postmenopausal women within the Melbourne Collaborative Cohort Study that included a random sample of 857 women and 197 breast cancer cases diagnosed during a mean of 9.2 years of follow-up. Concentrations of total estradiol, estrone sulfate, testosterone, DHEA sulfate, androstenedione, and sex hormone binding globulin were measured in plasma collected at baseline before diagnosis; free estradiol plasma co..View full abstract
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Awarded by National Health and Medical Research Council
Cohort recruitment was funded by VicHealth and The Cancer Council Victoria. This study was funded by grants from the National Health and Medical Research Council (251533, 209057, 504711) and The National Breast Cancer Foundation and was further supported by infrastructure provided by The Cancer Council Victoria. J.L. Hopper is a NHMRC Australia Fellow.