Consumption of animal products, their nutrient components and postmenopausal circulating steroid hormone concentrations
MT Brinkman, L Baglietto, K Krishnan, DR English, G Severi, HA Morris, JL Hopper, GG Giles
EUROPEAN JOURNAL OF CLINICAL NUTRITION | NATURE PUBLISHING GROUP | Published : 2010
BACKGROUND/OBJECTIVES: Little is known about nutritional factors that influence circulating concentrations of steroid hormones, which are consistently associated with risk of breast cancer for postmenopausal women. We aimed to investigate the association between consumption of animal products and the plasma concentrations of steroid hormones and sex hormone-binding globulin (SHBG). SUBJECTS/METHODS: Cross-sectional analysis was conducted on plasma from 766 naturally postmenopausal women. We measured plasma concentrations of steroid hormones and SHBG, and estimated dietary intakes using a 121-item food frequency questionnaire. Log-transformed values of hormone concentrations were regressed on..View full abstract
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Awarded by National Health and Medical Research Council
Recruitment of the cohort was funded by the VicHealth and The Cancer Council Victoria. This study was funded by grants from the National Health and Medical Research Council (251533, 209057) and the National Breast Cancer Foundation, and was further supported by the infrastructure provided by The Cancer Council Victoria.This study was made possible by the contribution of many people, including the original investigators and the diligent team who recruited the participants and who continue working on follow-up. We would like to express our gratitude to the many thousands of Melbourne residents who continue to participate in the study. We also acknowledge the contribution of Ms Sonia Dunn for assistance with the hormone measurements.