Family History, Mammographic Density, and Risk of Breast Cancer
Lisa J Martin, Olga Melnichouk, Helen Guo, Anna M Chiarelli, T Gregory Hislop, Martin J Yaffe, Salomon Minkin, John L Hopper, Norman F Boyd
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION | AMER ASSOC CANCER RESEARCH | Published : 2010
PURPOSE: Mammographic density is a strong and highly heritable risk factor for breast cancer. The purpose of this study was to examine the extent to which mammographic density explains the association of family history of breast cancer with risk of the disease. SUBJECTS AND METHODS: We carried out three nested case-control studies in screening programs that included in total 2,322 subjects (1,164 cases and 1,158 controls). We estimated the independent and combined associations of family history and percent mammographic density at baseline with subsequent breast cancer risk. RESULTS: After adjustment for age and other risk factors, compared with women with no affected first-degree relatives, ..View full abstract
Grants from the National Cancer Institute of Canada and the Canadian Breast Cancer Research Alliance. Dr. Boyd was supported by the Lee K. and Margaret Lau Chair in Breast Cancer Research. This research was funded in part by the Ontario Ministry of Health and Long Term Care. The views expressed do not necessarily reflect those of the OMOHLTC.