Common Genetic Variants Associated with Breast Cancer and Mammographic Density Measures That Predict Disease
Fabrice Odefrey, Jennifer Stone, Lyle C Gurrin, Graham B Byrnes, Carmel Apicella, Gillian S Dite, Jennifer N Cawson, Graham G Giles, Susan A Treloar, Dallas R English, John L Hopper, Melissa C Southey
CANCER RESEARCH | AMER ASSOC CANCER RESEARCH | Published : 2010
Mammographic density for age and body mass index (BMI) is a heritable risk factor for breast cancer. We aimed to determine if recently identified common variants associated with small gradients in breast cancer risk are associated with mammographic density. We genotyped 497 monozygotic and 330 dizygotic twin pairs and 634 of their sisters from 903 families for 12 independent variants. Mammographic dense area, percent dense area, and nondense area were measured by three observers using a computer-thresholding technique. Associations with mammographic density measures adjusted for age, BMI, and other determinants were estimated (a) cross-sectionally using a multivariate normal model for pedigr..View full abstract
Grant SupportNational Health and Medical Research Council (NHMRC) of Australia, National Breast Cancer Foundation, and Cancer Australia. J. Hopper is an Australian Fellow of the NHMRC and a Victorian Breast Cancer Research Consortium Group Leader. M. Southey is a NHMRC Senior Research Fellow.