Ibuprofen Treatment for Closure of Patent Ductus Arteriosus Is Not Associated With Increased Risk of Neuropathology
Michelle Loeliger, Amy Shields, Donald McCurnin, Ronald I Clyman, Bradley Yoder, Terrie E Inder, Sandra M Rees
PEDIATRIC RESEARCH | NATURE PUBLISHING GROUP | Published : 2010
Ibuprofen is an effective pharmacological intervention for closure of a patent ductus arteriosus (PDA) in preterm infants and is an alternative to surgical ligation; however, it is not certain whether ibuprofen treatment is associated with adverse effects on the brain. Therefore, this study examined neuropathological outcomes of ibuprofen therapy for a PDA. Fetal baboons were delivered at 125 d of gestation (dg; term ∼185 dg) by caesarean section, given surfactant, and ventilated for 14 d with positive pressure ventilation (PPV). Baboons were randomly allocated to receive either ibuprofen (PPV+ ibuprofen, n = 8) or no therapy (PPV, n = 5). Animals were killed on day 14 and brains assessed fo..View full abstract
Awarded by NIH
Awarded by NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
Supported by NIH Grant R01 HL074942 and in part by NIH Grants HL52636, HL56061, HL46691, HL77395, and HL52646.