Journal article

Membrane receptors: Structure and function of the relaxin family peptide receptors

Roy CK Kong, Patrick J Shilling, Derek K Lobb, Paul R Gooley, Ross AD Bathgate

MOLECULAR AND CELLULAR ENDOCRINOLOGY | ELSEVIER IRELAND LTD | Published : 2010

Abstract

The receptors for members of the relaxin peptide family have only recently been discovered and are G-protein-coupled receptors (GPCRs). Relaxin and insulin-like peptide 3 (INSL3) interact with the leucine-rich-repeat-containing GPCRs (LGRs) LGR7 and LGR8, respectively. These receptors show closest similarity to the glycoprotein hormone receptors and contain large ectodomains with 10 leucine-rich repeats (LRRs) but are unique members of the LGR family (class C) as they have an LDL class A (LDLa) module at their N-terminus. In contrast, relaxin-3 and INSL5 interact with another class of type I GPCRs which lack a large ectodomain, the peptide receptors GPCR135 and GPCR142, respectively. These r..

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Grants

Funding Acknowledgements

RCKK is a recipient of a Melbourne International Fee Remission Scholarship and a Melbourne International Research Scholarship, PJS of a Melbourne University Postgraduate Research Scholarship and RADB of an Australian National Health and Medical Research (NHMRC) Senior Research Fellowship.