Journal article

Parent of origin effects on age at colorectal cancer diagnosis

Noralane M Lindor, Karl G Rabe, Gloria M Petersen, Helen Chen, Bharati Bapat, John Hopper, Joanne Young, Mark Jenkins, John Potter, Polly Newcomb, Allyson Templeton, Loic LeMarchand, John Grove, Michael R Burgio, Robert Haile, Jane Green, Michael O Woods, Daniela Seminara, Paul J Limburg, Stephen N Thibodeau

INTERNATIONAL JOURNAL OF CANCER | WILEY | Published : 2010

Abstract

Genomic imprinting refers to a parent-of-origin specific effect on gene expression. At least 1% of genes in the human genome are modulated in this manner. We sought evidence for genomic imprinting in colorectal cancer by studying the ages at diagnosis in the offspring of 2,061 parent-child pairs in which both parent and child were affected by nonsyndromic colorectal cancer. Families were ascertained through the colon Cancer Family Registry [http://epi.grants.cancer.gov/CFR/] from both population-based and clinic-based sources. We found that the affected offspring of affected fathers were on average younger than offspring of affected mothers (55.8 vs. 53.7 years; p = 0.0003), but when divided..

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Grants

Awarded by National Cancer Institute, National Institutes of Health


Awarded by Australian Colorectal Cancer Family Registry


Awarded by USC Familial Colorectal Neoplasia Collaborative Group


Awarded by Mayo Clinic Cooperative Family Registry for Colon Cancer Studies


Awarded by Ontario Registry for Studies of Familial Colorectal Cancer


Awarded by Seattle Colorectal Cancer Family Registry


Awarded by University of Hawaii Colorectal Cancer Family Registry


Awarded by University of California, Irvine Informatics Center


Awarded by NATIONAL CANCER INSTITUTE


Funding Acknowledgements

Grant sponsor: National Cancer Institute, National Institutes of Health; Grant number: RFA #CA-95-011; Grant sponsor: Australian Colorectal Cancer Family Registry; Grant number: UO1 CA097735; Grant sponsor: USC Familial Colorectal Neoplasia Collaborative Group; Grant number: UO1 CA074799; Grant sponsor: Mayo Clinic Cooperative Family Registry for Colon Cancer Studies; Grant number: UO1 CA074800; Grant sponsor: Ontario Registry for Studies of Familial Colorectal Cancer; Grant number: UO1 CA074783; Grant sponsor: Seattle Colorectal Cancer Family Registry; Grant number: UO1 CA074794; Grant sponsor: University of Hawaii Colorectal Cancer Family Registry; Grant number: UO1 CA074806; Grant sponsor: University of California, Irvine Informatics Center; Grant number: UO1 CA078296