Journal article

Lynch Syndrome-Associated Breast Cancers: Clinicopathologic Characteristics of a Case Series from the Colon Cancer Family Registry

Michael D Walsh, Daniel D Buchanan, Margaret C Cummings, Sally-Ann Pearson, Sven T Arnold, Mark Clendenning, Rhiannon Walters, Diane M McKeone, Amanda B Spurdle, John L Hopper, Mark A Jenkins, Kerry D Phillips, Graeme K Suthers, Jill George, Jack Goldblatt, Amanda Muir, Kathy Tucker, Elise Pelzer, Michael R Gattas, Sonja Woodall Show all



PURPOSE: The recognition of breast cancer as a spectrum tumor in Lynch syndrome remains controversial. The aim of this study was to explore features of breast cancers arising in Lynch syndrome families. EXPERIMENTAL DESIGN: This observational study involved 107 cases of breast cancer identified from the Colorectal Cancer Family Registry (Colon CFR) from 90 families in which (a) both breast and colon cancer co-occurred, (b) families met either modified Amsterdam criteria, or had at least one early-onset (<50 years) colorectal cancer, and (c) breast tissue was available within the biospecimen repository for mismatch repair (MMR) testing. Eligibility criteria for enrollment in the Colon CFR are..

View full abstract


Awarded by National Cancer Institute, NIH

Awarded by Mayo Clinic Cooperative Family Registry for Colon Cancer Studies

Awarded by Australasian Colorectal Cancer Family Registry

Funding Acknowledgements

National Cancer Institute, NIH under RFA no. CA-95-011, and through cooperative agreements with the Australasian Colorectal Cancer Family Registry (U01 CA097735) and the Mayo Clinic Cooperative Family Registry for Colon Cancer Studies (U01 CA074800).