Journal article

Genes involved with folate uptake and distribution and their association with colorectal cancer risk

Jane C Figueiredo, A Joan Levine, Won H Lee, David V Conti, Jenny N Poynter, Peter T Campbell, David Duggan, Juan Pablo Lewinger, Maria Elena Martinez, Cornelia M Ulrich, Polly Newcomb, John Potter, Paul J Limburg, John Hopper, Mark A Jenkins, Loic Le Marchand, John A Baron, Robert W Haile

CANCER CAUSES & CONTROL | SPRINGER | Published : 2010

Abstract

Folate status is an important predictor of colorectal cancer risk. Common genetic variants in genes involved in regulating cellular folate levels might also predict risk, but there are limited data on this issue. We conducted a family-based case-control association study of variants in four genes involved in folate uptake and distribution: FOLR1, FPGS, GGH and SLC19A1, using 1,750 population-based and 245 clinic-based cases of pathologically confirmed colorectal cancer and their unaffected relatives participating in the Colon Cancer Family Registries. Standardized questionnaires, administered to all participants, collected information on risk factors and diet. Standard molecular techniques w..

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Grants

Awarded by National Cancer Institute, National Institutes of Health


Awarded by Australasian Colorectal Cancer Family Registry


Awarded by USC Familial Colorectal Neoplasia Collaborative


Awarded by Mayo Clinic Cooperative Family Registry for Colon Cancer Studies


Awarded by Ontario Registry for Studies of Familial Colorectal Cancer


Awarded by Seattle Colorectal Cancer Family Registry


Awarded by University of Hawaii Colorectal Cancer Family Registry


Awarded by NCI


Awarded by National Cancer Institute of Canada


Awarded by NATIONAL CANCER INSTITUTE


Funding Acknowledgements

This work was supported by the National Cancer Institute, National Institutes of Health under RFA # CA-95-011 and through cooperative agreements with the Australasian Colorectal Cancer Family Registry (U01 CA097735), the USC Familial Colorectal Neoplasia Collaborative Group (U01 CA074799), the Mayo Clinic Cooperative Family Registry for Colon Cancer Studies (U01 CA074800), the Ontario Registry for Studies of Familial Colorectal Cancer (U01 CA074783), the Seattle Colorectal Cancer Family Registry (U01 CA074794), and the University of Hawaii Colorectal Cancer Family Registry (U01 CA074806) as well as NCI T32 CA009142 (JNP), NCI R01 CA112237 (RWH), NCI PO1 CA41108 (MEM), CA23074 (MEM) and CA95060 (MEM). P. T. C. and J. C. F. were supported in part by National Cancer Institute of Canada post-PhD Fellowships (# 18735 and # 17602).