Journal article
Risk of endometrial cancer for women diagnosed with HNPCC-related colorectal carcinoma
A Obermair, DR Youlden, JP Young, NM Lindor, JA Baron, P Newcomb, S Parry, JL Hopper, R Haile, MA Jenkins
International Journal of Cancer | JOHN WILEY & SONS INC | Published : 2010
DOI: 10.1002/ijc.25501
Abstract
The risk of endometrial cancer (EC) subsequent to a diagnosis of colorectal cancer in women with a germline mutation in a mismatch repair gene [Lynch syndrome or hereditary non-polyposis colon cancer (HNPCC)] is unknown. We estimated the risk of EC following a diagnosis of colorectal carcinoma (CRC) for women with Lynch syndrome. A retrospective cohort study was performed on women diagnosed with CRC with a germline mutation in a mismatch repair (MMR) gene (Lynch syndrome cases), and women with microsatellite stable (MSS) CRC who were not known to carry a germline mutation (non-Lynch cases), identified from the Colon Cancer Family Registry. The incidence of EC following CRC was estimated and ..
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Awarded by National Cancer Institute
Funding Acknowledgements
The Colon CFR work was supported by the National Cancer Institute, National Institutes of Health under RFA #CA-95-011 and through cooperative agreements with the members of the Colon Cancer Family Registry (CFR) and principal investigators.