Journal article
Serum zinc is decreased in Alzheimer's disease and serum arsenic correlates positively with cognitive ability
L Baum, IHS Chan, SKK Cheung, WB Goggins, V Mok, L Lam, V Leung, E Hui, C Ng, J Woo, HFK Chiu, BCY Zee, W Cheng, MH Chan, S Szeto, V Lui, J Tsoh, AI Bush, CWK Lam, T Kwok
Biometals | Published : 2010
Abstract
Zinc, copper, and iron aggregate Aβ and accumulate in Alzheimer's disease (AD) plaques. Some metals are increased in AD vs. control serum. The authors examined levels of 12 metals in serum of 44 AD and 41 control subjects. Zinc decreased from 12.3 to 10.9 μmol/L (means, p = 0.0007). Arsenic positively correlated with Mini-Mental State Examination score (p<0.0001). Zinc deposition in brain amyloid might deplete zinc from other body compartments, such as serum. The arsenic correlation might be caused by the major contribution of seafood consumption to intake of both arsenic and docosahexaenoic acid, of which the latter may delay AD. © Springer Science+Business Media.
Grants
Funding Acknowledgements
Supported by a grant from The Chinese University of Hong Kong Institute of Chinese Medicine, by a Chinese University of Hong Kong Direct Grant for Research, and by a BUPA Foundation medical research grant.