Journal article
Phenotypic diversity in patients with multiple serrated polyps: A genetics clinic study
DD Buchanan, K Sweet, M Drini, MA Jenkins, AK Win, M Gattas, MD Walsh, M Clendenning, D McKeone, R Walters, A Roberts, A Young, H Hampel, JL Hopper, J Goldblatt, J George, GK Suthers, K Phillips, GP Young, E Chow Show all
International Journal of Colorectal Disease | SPRINGER | Published : 2010
Open access
Abstract
Objective: Hyperplastic polyposis is a colonic polyposis condition of unknown aetiology. The purpose of this study was to examine the spectrum of phenotypic variation in patients with multiple serrated polyps as a basis for gene discovery. Methods: One hundred and twenty-six patients with multiple (≥5) serrated polyps were recruited to the study. Polyp counts were extracted from histology and colonoscopy reports. Ethnicity was self-reported. Family history of cancer data were derived from pedigrees. Ascertainment status was classified as either index case or identified by screening. Results: The average reported polyp count was 39. Patients with highest polyp numbers were more likely to be m..
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Awarded by National Cancer Institute
Funding Acknowledgements
This work was supported by grants from the Cancer Council Queensland, the Hicks Foundation in Victoria, and the National Cancer Institute 1R01CA123010 (Genetics of Serrated Neoplasia). The content of this manuscript does not necessarily reflect the views or policies of the National Cancer Institute nor does mention of trade names, commercial products, or organisations imply endorsement by the US Government. JY is a Cancer Council Queensland Senior Research Fellow. MD and EC were Hicks Foundation in Victoria Fellows.