Inhibition of Porphyromonas gingivalis Biofilm by Oxantel
Stuart Dashper, Ching-Seng Ang, Sze Wei Liu, Rita Paolini, Paul Veith, Eric Reynolds
Antimicrobial Agents and Chemotherapy | AMER SOC MICROBIOLOGY | Published : 2010
Porphyromonas gingivalis is a major pathogen of chronic periodontitis and exists in a biofilm on the surface of the tooth root. Oxantel, a cholinergic anthelmintic and fumarate reductase inhibitor, significantly inhibited biofilm formation by P. gingivalis and disrupted established biofilms at concentrations below its MIC against planktonic cells. Oxantel was more effective against P. gingivalis in biofilm than metronidazole, a commonly used antibiotic for periodontitis.
This work was supported by the Australian National Health and Medical Research Council and an International Association for Dental Research/Glaxo Smith Kline Innovation in Oral Care Award. C. S. A. acknowledges the support of the IPRS, MIRS, and CRC scholarships from The University of Melbourne and The CRC for Oral Health Science.