Journal article
Hypertension and atrial fibrillation: Evidence of progressive atrial remodeling with electrostructural correlate in a conscious chronically instrumented ovine model
DH Lau, L MacKenzie, DJ Kelly, PJ Psaltis, AG Brooks, M Worthington, A Rajendram, DR Kelly, Y Zhang, P Kuklik, AJ Nelson, CX Wong, SG Worthley, M Rao, RJ Faull, J Edwards, DA Saint, P Sanders
Heart Rhythm | Published : 2010
Abstract
Background: Hypertension accounts for more atrial fibrillation (AF) than any other predisposing factor. Objective: The purpose of this study was to characterize the time course, extent, and electrostructural correlation of atrial remodeling in chronic hypertension. Methods: Thirty-two sheep were studied: 21 with induced "one-kidney, one-clip" hypertension and 11 controls. Sequential closed-chest electrophysiologic studies were performed in 12 conscious animals (6 hypertensive, 6 controls) to evaluate progressive remodeling over 15 weeks. Additional atrial structural/functional analyses were performed in 5 controls and at 5, 10, and 15 weeks of hypertension (five per time point) via histology..
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Funding Acknowledgements
This study was supported in part by a Grant-in-Aid (G-08A-3653) from the National Heart Foundation of Australia (NHFA). Dr. Lau is supported by a medical postgraduate scholarship from the National Health and Medical Research Council (NHMRC) of Australia, the Earl Bakken Electrophysiology Scholarship from the University of Adelaide, and a biomedical research scholarship from Kidney Health Australia. Dr. Psaltis is supported by a medical postgraduate scholarship from the NHMRC of Australia. Drs. Brooks and Sanders are supported by the NHFA. Dr. Sanders reports having served on the advisory board of and having received lecture fees and research funding from Bard Electrophysiology, Biosense-Webster, Medtronic, and St. Jude Medical.