Upstream Regulation of the Hippo Size Control Pathway
Felix A Grusche, Helena E Richardson, Kieran F Harvey
CURRENT BIOLOGY | CELL PRESS | Published : 2010
The newly discovered Salvador-Warts-Hippo (SWH) pathway is a key regulator of tissue growth during both development and disease. The first identified components of this pathway represent core downstream effector proteins: the kinases Warts and Hippo; the adaptor proteins Salvador and Mats; and the transcriptional co-activator Yorkie. More recently, a surprising number of proteins have been implicated as upstream regulators of the SWH pathway, including: the planar cell polarity cadherins Fat and Dachsous; the FERM-domain proteins Expanded and Merlin; the WW-domain protein Kibra; the Ras-association family protein dRASSF; and the apicobasal polarity proteins lethal giant larvae, atypical prot..View full abstract
We thank Ryan Galea for help with Figure 1. F.A.G. is supported by an International Postgraduate Research and Fee Remission Fellowship from the University of Melbourne, H.E.R. is supported by a Senior NHMRC Research Fellowship and K.F.H. by a Sylvia and Charles Viertel Senior Medical Research Fellowship.