Journal article

Reduced connectivity of the auditory cortex in patients with auditory hallucinations: a resting state functional magnetic resonance imaging study

M Gavrilescu, S Rossell, GW Stuart, TL Shea, H Innes-Brown, K Henshall, C McKay, AA Sergejew, D Copolov, GF Egan

PSYCHOLOGICAL MEDICINE | CAMBRIDGE UNIV PRESS | Published : 2010

Abstract

BACKGROUND: Previous research has reported auditory processing deficits that are specific to schizophrenia patients with a history of auditory hallucinations (AH). One explanation for these findings is that there are abnormalities in the interhemispheric connectivity of auditory cortex pathways in AH patients; as yet this explanation has not been experimentally investigated. We assessed the interhemispheric connectivity of both primary (A1) and secondary (A2) auditory cortices in n=13 AH patients, n=13 schizophrenia patients without auditory hallucinations (non-AH) and n=16 healthy controls using functional connectivity measures from functional magnetic resonance imaging (fMRI) data. METHOD:..

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Grants

Awarded by NHMRC


Funding Acknowledgements

This work was supported by grant NHMRC 236025 and funding from The Garnett Passe and Rodney Williams Memorial Foundation. G.E. acknowledges support from NHMRC fellowship 400317. S.R. and M.G. acknowledge support from MHRI core funding; and H.I-B. from Cognitive Neurobiology of Psychosis Platform at Neurosciences Victoria. We thank Ms Erica Neill for conducting the participant interviews and clinical testing.