Decreased Expression of the Rat Myometrial Relaxin Receptor (RXFP1) in Late Pregnancy Is Partially Mediated by the Presence of the Conceptus
Lenka A Vodstrcil, Oksana Shynlova, Jill W Verlander, Mary E Wlodek, Laura J Parry
BIOLOGY OF REPRODUCTION | OXFORD UNIV PRESS INC | Published : 2010
The actions of relaxin are mediated by relaxin family peptide receptor 1 (Rxfp1). In pregnant mice, myometrial Rxfp1 expression decreases at term, coinciding with the highest level of circulating relaxin. This down-regulation in Rxfp1 in reproductive tissues has not been investigated in other pregnant animals, nor are the regulatory mechanisms known. In the present study, we examined Rxfp1 gene and protein expression in the nonpregnant, pregnant, and postpartum rat uterus. The potential effects of local conceptus-derived factors on Rxfp1 expression were then examined in unilaterally pregnant rats. Immunoreactive RXFP1 was predominantly detected in the circular smooth muscle layer in the myom..View full abstract
Awarded by CIHR
Supported by grants from the NH&MRC Australia (M.E.W.), CIHR 37775 (O.S.), and The University of Melbourne Research Grants Scheme (L.J.P.). L.A.V. was funded by an NH&MRC Australia Dora Lush Postgraduate Scholarship and an Albert Shimmins Memorial Fund Award.