Identification of Attractive Drug Targets in Neglected-Disease Pathogens Using an In Silico Approach
Gregory J Crowther, Dhanasekaran Shanmugam, Santiago J Carmona, Maria A Doyle, Christiane Hertz-Fowler, Matthew Berriman, Solomon Nwaka, Stuart A Ralph, David S Roos, Wesley C Van Voorhis, Fernan Agueero
PLOS NEGLECTED TROPICAL DISEASES | PUBLIC LIBRARY SCIENCE | Published : 2010
BACKGROUND: The increased sequencing of pathogen genomes and the subsequent availability of genome-scale functional datasets are expected to guide the experimental work necessary for target-based drug discovery. However, a major bottleneck in this has been the difficulty of capturing and integrating relevant information in an easily accessible format for identifying and prioritizing potential targets. The open-access resource TDRtargets.org facilitates drug target prioritization for major tropical disease pathogens such as the mycobacteria Mycobacterium leprae and Mycobacterium tuberculosis; the kinetoplastid protozoans Leishmania major, Trypanosoma brucei, and Trypanosoma cruzi; the apicomp..View full abstract
This work was supported by grants from the United Nations Development Programme/World Bank/World Health Organization Special Programme for Research and Training in Tropical Diseases (http://apps.who.int/tdr/). The funders had no role in data collection and analysis or decision to publish; however, Solomon Nwaka of WHO/TDR did help design the study and revise the manuscript and consequently is listed as a coauthor.