Journal article
Maternal and umbilical cord androgen concentrations do not predict digit ratio (2D:4D) in girls: A prospective cohort study
M Hickey, DA Doherty, R Hart, RJ Norman, E Mattes, HC Atkinson, DM Sloboda
Psychoneuroendocrinology | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2010
Abstract
Digit ratio (2D:4D) is widely used as a marker of prenatal androgen exposure. However, there are no published prospective studies where prenatal androgen exposure has been measured and correlated with digit ratio in adult life. We aimed to establish the prospective relationship between prenatal androgen exposure in the second and third trimesters of pregnancy (as measured by maternal circulating androgen concentrations and umbilical cord androgen concentrations) and digit ratio in adolescent girls. Androgen concentrations (testosterone, free androgen index, androstenedione, DHEAS) and sex hormone binding globulin (SHBG) were measured in stored plasma samples from pregnant mothers at 18 (n= 1..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
This study was funded by the National Health and Medical Research Council of Australia (project grant number 403968) and the Women and Infants Research Foundation of Western Australia. Professor Martha Hickey is funded by an NHMRC Clinical Career Development Award. The funding body had no further role in any stage of this research.