Effects of Conformational Restriction of 2-Amino-3-benzoylthiophenes on A(1) Adenosine Receptor Modulation

Luigi Aurelio; Celine Valant; Bernard L Flynn; Patrick M Sexton; Jonathan M White; Arthur Christopoulos; Peter J Scammells

Journal article

Effects of Conformational Restriction of 2-Amino-3-benzoylthiophenes on A(1) Adenosine Receptor Modulation

Luigi Aurelio, Celine Valant, Bernard L Flynn, Patrick M Sexton, Jonathan M White, Arthur Christopoulos, Peter J Scammells

Journal of Medicinal Chemistry | AMER CHEMICAL SOC | Published : 2010

DOI: 10.1021/jm1008538

University of Melbourne Researchers

Jonathan White Author Chemistry

Related Projects (1)

X-ray Molecular Structure Elucidation Facility (MSEF)

X-ray diffraction plays a key role in identification and molecular characterization. X-ray techniques are the single most widely used analyt..

Grants

Awarded by Australian Research Council

Awarded by National Health and Medical Research Council (NHMRC) of Australia

Funding Acknowledgements

This research was supported by Discovery grant DP0877497 of the Australian Research Council and Program grant 519461 of the National Health and Medical Research Council (NHMRC) of Australia. A.C. is a Senior, and P.M.S. a Principal Research Fellow, of the NHMRC. We are grateful to Dr. Michael Crouch, TGR Biosciences, Adelaide, for generously providing the ERK SureFire Alphascreen kit reagents.