Journal article
Risk factors for colorectal cancer in patients with multiple serrated polyps: A cross-sectional case series from genetics clinics
DD Buchanan, K Sweet, M Drini, MA Jenkins, AK Win, DR English, MD Walsh, M Clendenning, DM McKeone, RJ Walters, A Roberts, SA Pearson, E Pavluk, JL Hopper, MR Gattas, J Goldblatt, J George, GK Suthers, KD Phillips, S Woodall Show all
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2010
Abstract
Background: Patients with multiple serrated polyps are at an increased risk for developing colorectal cancer (CRC). Recent reports have linked cigarette smoking with the subset of CRC that develops from serrated polyps. The aim of this work therefore was to investigate the association between smoking and the risk of CRC in high-risk genetics clinic patients presenting with multiple serrated polyps. Methods and Findings: We identified 151 Caucasian individuals with multiple serrated polyps including at least 5 outside the rectum, and classified patients into non-smokers, current or former smokers at the time of initial diagnosis of polyposis. Cases were individuals with multiple serrated poly..
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Awarded by National Cancer Institute
Funding Acknowledgements
This work was supported by grants from the Cancer Council Queensland, the Hicks Foundation in Victoria, and the National Cancer Institute through 1R01CA123010 (Genetics of Serrated Neoplasia) and RFA #CA-95-011 through cooperative agreements with the Australasian Colorectal Cancer Family Registry (U01 CA097735). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.