Journal article
Structural decay of bone microarchitecture in men with prostate cancer treated with androgen deprivation therapy
EJ Hamilton, A Ghasem-Zadeh, E Gianatti, D Lim-Joon, D Bolton, R Zebaze, E Seeman, JD Zajac, M Grossmann
Journal of Clinical Endocrinology and Metabolism | Published : 2010
DOI: 10.1210/jc.2010-0902
Abstract
Context: Androgen deprivation therapy (ADT) used in the treatment of prostate cancer reduces bone mineral density (BMD) and predisposes to fractures. The structural basis of the BMD deficit and bone fragility is uncertain. Objective and Patients: We investigated changes in bone microarchitecture in 26 men (70.6 ± 6.8 yr) with nonmetastatic prostate cancer during the first year of ADT using the new technique of high-resolution peripheral quantitative computed tomography. Design and Setting: We conducted a 12-month prospective observational study in the setting of a tertiary referral center. Results: After 12 months of ADT, total volumetric density decreased by 5.2 ± 5.4% at the distal radius ..
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Funding Acknowledgements
E.J.H. was supported by scholarships from the Royal Australasian College of Physicians (Rowling Trash and Treasure and Osteoporosis Australia research entry grants) as well as the University of Melbourne Medical Faculty (Viola Edith Reid scholarship) to undertake this project as part of Ph.D. studies. M.G. was supported by a National Health and Medical Research Council of Australia Health Professional Research Fellowship and by fellowships from the Royal Australasian College of Physicians as well as from Osteoporosis Australia.