Journal article
Relationship between atrophy and β-amyloid deposition in Alzheimer disease
G Chételat, VL Villemagne, P Bourgeat, KE Pike, G Jones, D Ames, KA Ellis, C Szoeke, RN Martins, GJ O'Keefe, O Salvado, CL Masters, CC Rowe
Annals of Neurology | Published : 2010
DOI: 10.1002/ana.21955
Abstract
Objective: Elucidating the role of aggregated β-amyloid in relation to gray matter atrophy is crucial to the understanding of the pathological mechanisms of Alzheimer disease and for the development of therapeutic trials. The present study aims to assess this relationship. Methods: Brain magnetic resonance imaging and [11C]Pittsburgh compound B (PiB)-positron emission tomography scans were obtained from 94 healthy elderly subjects (49 with subjective cognitive impairment), 34 patients with mild cognitive impairment, and 35 patients with Alzheimer disease. The correlations between global and regional neocortical PiB retention and atrophy were analyzed in each clinical group. Results: Global a..
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Funding Acknowledgements
This study was supported by the Commonwealth Scientific Industrial Research Organization (CSIRO) through the Australian Imaging, Biomarkers and Lifestyle (AIBL) flagship study of aging, the Austin Hospital Medical Research Foundation, Neurosciences Victoria, and the University of Melbourne.