Journal article
Salt supplementation blunts the blood pressure response to telmisartan with or without hydrochlorothiazide in hypertensive patients with type 2 diabetes
EI Ekinci, G Thomas, RJ MacIsaac, C Johnson, C Houlihan, S Panagiotopoulos, E Premaratne, H Hao, S Finch, C O'Callaghan, G Jerums
Diabetologia | Published : 2010
Abstract
Aims/hypothesis We assessed the effects of sodium chloride (NaCl) supplementation on the blood pressure response to treatment with telmisartan with or without hydrochlorothiazide in hypertensive patients with type 2 diabetes and habitually high (HDS, sodium excretion >200 mmol/24 h on two out of three consecutive occasions) or low (LDS, sodium excretion <100 mmol/24 h on two out of three consecutive occasions) salt intake. Methods Patients received 4 weeks of telmisartan followed by 4 weeks of telmisartan plus hydrochlorothiazide. In a double-blind randomised fashion, patients received sodium chloride (NaCl, 100 mmol/24 h) or placebo capsules in addition to their habitual salt intake during ..
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Funding Acknowledgements
We thank A. Akdeniz, J. Winikoff, M. Millard and the staff of the Vascular, Laboratory and Clinical Pharmacology Departments at Austin Health for their assistance. In addition, we would like to thank the patients who participated in this demanding study. This work was supported by a Pfizer Cardiovascular-Lipid grant and an unconditional educational grant from Boehringer Ingelheim. During the period of this work, E. I. Ekinci was supported by grants from the Austin Hospital Medical Research Foundation and the National Health and Medical Research Council.