Conference Proceedings
Differential stimulation of on and off retinal ganglion cells: A modeling study
T Kameneva, H Meffin, AN Burkitt
2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society Embc 10 | IEEE | Published : 2010
Abstract
A model of the electrophysiological properties of ON and OFF retinal ganglion cells (RGCs) was constrained and validated using experimental data from the literature. Our simulations support experimental findings that differences in the magnitude of the T-type Ca2+ current explain differences in the intrinsic electrophysiology of ON and OFF RGCs. The models are used to investigate the potential for differential stimulation of ON and OFF RGCs during neuroprosthetic stimulation with sinusoidal current. The model predicts that OFF cells fire preferential over ON cells in a frequency band around 10 Hz. © 2010 IEEE.